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KMID : 0603820160220040127
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Journal of Experimental & Biomedical Science
2016 Volume.22 No. 4 p.127 ~ p.139
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Antiplatelet Effects of Cordycepin-Enriched WIB-801CE from Cordyceps militaris: Involvement of Thromboxane A2, Serotonin, Cyclooxygenase-1, Thromboxane A2 Synthase, Cytosolic Phospholipase A2
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Ok Woo-Jeong
Nam Gi-Suk
Kim Min-Ji
Kwon Hyuk-Woo
Kim Hyun-Hong
Shin Jung-Hae
Lim Deok-Hwi
Kwon Ho-Kyun
Lee Chang-Hwan
Chung Soo-Hak
Kim Jong-Lae
Park Hwa-Jin
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Abstract
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A species of the fungal genus Cordyceps has been used as an ingredient of traditional Chinese medicine. In this study, we prepared cordycepin-enriched WIB-801CE, an ethanol extract from culture solution of Cordyceps militaris-hypha, and evaluated its antiplatelet effects on human platelet aggregation. WIB-801CE dose-dependently inhibited ADP-, collagen-, and thrombin-induced platelet aggregation. These antiplatelet effects by WIB-801CE were associated with the attenuation of thromboxane A2 (TXA2) production and serotonin release by ADP, collagen, and thrombin. The inhibition of TXA2 production by WIB-801CE was due to the inhibition of cyclooxygenase-1, TXA2 synthase, and cytosolic phospholipase A2 activity. Therefore, these data suggest that WIB-801CE may be a beneficial component against protection from platelet aggregation-mediated thrombotic disease.
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KEYWORD
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Cordycepin , WIB-801CE , TXA2 , Serotonin , TXAS , COX-1 , cPLA2
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